IMGT Web resources: IMGT repertoire

Alignment of alleles: Atlantic cod (Gadus morhua) IGHV2S1

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Germline genomic sequences are needed to confirm if the nucleotide substitutions result from somatic mutations or correspond to allelic polymorphisms.

                                  1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16  17  18  19  20
                                 G   Q   Q   L   T   S   S   E   S       V   V   K   R   Q   G   E   P   V   T
  X76510  ,IGHV2S1*01, 112-12   GGC CAG CAA CTC ACC TCC TCA GAA TCG ... GTG GTC AAA AGG CAA GGA GAA CCG GTT ACA

  AJ274709,IGHV2S1*02, 19-07a   --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- ---

                                                        ___________________CDR1-IMGT____________________
                                 21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40
                                 L   S   C   H   V   T   G   V   S   L   T   Y                           L   H
  X76510  ,IGHV2S1*01, 112-12   CTG TCC TGT CAC GTG ACC GGA GTC TCC CTC ACT TAT ... ... ... ... ... ... CTT CAC

  AJ274709,IGHV2S1*02, 19-07a   --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... --- ---

                                                                                            _______________CDR2-
                                 41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                 W   I   R   Q   R   S   G   H   G   L   E   W   I   G   R   I   D   D   G   T
  X76510  ,IGHV2S1*01, 112-12   TGG ATT CGC CAG AGG TCA GGA CAT GGC CTG GAG TGG ATT GGA CGG ATA GAT GAT GGA ACC
                                                                                                         E  
  AJ274709,IGHV2S1*02, 19-07a   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -A- ---

                                IMGT________________
                                 61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79  80
                                 G   T               I   F   A   A   S   L   Q       G   Q   F   T   I   T   K
  X76510  ,IGHV2S1*01, 112-12   GGA ACA ... ... ... ATT TTT GCA GCG TCT CTT CAA ... GGG CAG TTC ACC ATC ACC AAA

  AJ274709,IGHV2S1*02, 19-07a   --- --- ... ... ... --- --- --- --- --- --- --- ... --- --- --- --- --- --- ---

                                 81  82  83  84  85  86  87  88  89  90  91  92  93  94  95  96  97  98  99 100
                                 D   S   T   R   E   E   V   Y   L   N   V   K   S   L   K   P   E   D   S   A
  X76510  ,IGHV2S1*01, 112-12   GAC AGC ACC AGA GAG GAG GTT TAC TTA AAT GTG AAG AGT CTG AAG CCA GAG GAC TCA GCT

  AJ274709,IGHV2S1*02, 19-07a   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                CDR3-IMGT
                                101 102 103 104 105 106 
                                 L   Y   Y   C   A   K
  X76510  ,IGHV2S1*01, 112-12   CTT TAT TAT TGT GCT AAA     #c

  AJ274709,IGHV2S1*02, 19-07a   --- --- --- --- --- ---     #c

#c: rearranged cDNA

This alignment of allele is automatically generated by Mehdi Yousfi alignment of allele tool.

Created: 21/01/2002
Author: Nathalie Bosc